Chemotherapy-Induced Kidney Disorders: A Serious Complication of Cancer Treatment

Abstract

Background: Chemotherapy is a common treatment for cancer patients, but it can cause a range of complications, including kidney disorders. This study aimed to determine the prevalence of chemotherapy-induced kidney disorders in cancer patients in Hajjah City and identify the risk factors associated with their development. Aims: The study aimed to determine the prevalence of chemotherapy-induced kidney disorders in cancer patients in Hajjah City, identify the demographic characteristics of the study population, and determine the risk factors associated with the development of kidney disorders. Materials and Methods: The study included 342 cancer patients in Hajjah City who were receiving chemotherapy. Demographic data were collected, and kidney function was monitored during chemotherapy. Multivariate logistic regression analysis was used to identify the risk factors associated with kidney disorders. Results: The study found that 31.3% of cancer patients in Hajjah City developed kidney disorders during their chemotherapy treatment. Specifically, 17.3% of patients developed acute kidney injury (AKI), and 14.0% developed chronic kidney disease (CKD). Breast cancer was the most common cancer type, accounting for 27.5% of patients. Multivariate logistic regression analysis identified age, diabetes, and platinum-based chemotherapy as significant risk factors for kidney disorders in cancer patients. Conclusion: The study's findings highlight the high prevalence of chemotherapy-induced kidney disorders in cancer patients in Hajjah City and the importance of monitoring kidney function in this population. The identified risk factors can help healthcare professionals take proactive steps to detect kidney disorders early and manage them appropriately, potentially improving patient outcomes and reducing the risk of morbidity and mortality. The study underscores the need for future research to confirm these findings in larger and more diverse populations and identify effective strategies for preventing and managing chemotherapy-induced kidney disorders.