An Innovative Breast Cancer Treatment Using Turmeric Leaf Oil Encapsulated Nanoemulgels

Abstract

There are several uses for turmeric oil made from the leaves in the food and pharmaceutical industries. The effectiveness of turmeric leaf oil in treating cancer has been documented in numerous trials. The best technique to encapsulate it is via nanoemulsion technology, which can overcome its drawbacks including instability and a hydrophobic character that inhibits its biological activity. The objective of this research was to develop a nanoemulgel containing ethanol as a co-surfactant, tween 80 as a surfactant, and turmeric leaf oil (TLO) as a surfactant in order to describe it and evaluate its anticancer potential against the MCF-7 (human breast cancer) cell line. With an entrapment efficiency range of 67.72–85.13 percent, the mean particle size was 175.4 nm. According to the results of the in-vitro cytotoxicity study, TLO nanoemulgel had 28.56% cell viability after 24 hours and an IC50 value of 59.84 g/ml.